TBOPP

TBOPP is a selective inhibitor of DOCK1 with an IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with high affinity (Kd of 7.1 μM), has anti-tumor activity for broader types of tumors[1].

Product Specifications

CAS Number

[1996629-79-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DOCK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tbopp.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CC(S(=O)(N2CCCC2)=O)=CN1CC(C3=CC=C(C4=CC=CC(C(F)(F)F)=C4)C=C3)=O

Molecular Formula

C24H21F3N2O4S

Molecular Weight

490.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1. Cell Rep. 2017 May 2;19 (5) :969-980.