GPR84 antagonist 3
GPR84 antagonist 3 (compound 42) is a potent GPR84 (G-protein-coupled receptor 84) antagonist. GPR84 antagonist 3 inhibits GTPγS, with a pIC50 of 8.28. GPR84 antagonist 3 has a favorable pharmacokinetic profile suitable[1].
Product Specifications
CAS Number
2815263-05-7
UNSPSC
12352005
Target
GPR84
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gpr84-antagonist-3.html
Purity
98.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N1(CC2=CC=C(C3=C(C4=CC=CC=C4)N=C(CC5=CNC6=C5C=CC=C6)N=N3)C=C2)CCOCC1
Molecular Formula
C29H27N5O
Molecular Weight
461.56
References & Citations
[1]Mahindra A, et al. Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. J Med Chem. 2022 Aug 10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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