GNE-0439
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
Product Specifications
CAS Number
1241902-40-8
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gne-0439.html
Purity
99.11
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O
Molecular Formula
C21H31NO3
Molecular Weight
345.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7
Available Sizes
Frequently Asked Questions
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