(-) -Epipodophyllotoxin
(-) -Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-) -Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
Product Specifications
CAS Number
[4375-07-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-epipodophyllotoxin.html
Purity
99.95
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1[C@]([C@]2([H])CO1)([H])[C@@](C(C=C3OC)=CC(OC)=C3OC)([H])C4=CC(OCO5)=C5C=C4[C@H]2O
Molecular Formula
C22H22O8
Molecular Weight
414.41
Precautions
H315, H319, H320
References & Citations
[1]Magedov IV, et, al. Reengineered epipodophyllotoxin. Chem Commun (Camb) . 2012 Oct 28; 48 (84) : 10416-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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