Obtusifoliol
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively[1].
Product Specifications
CAS Number
16910-32-0
UNSPSC
12352211
Target
Cytochrome P450; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/obtusifoliol.html
Purity
99.86
Solubility
DMSO : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C=C(C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2(C)C(CC[C@@]3([H])[C@H](C)[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Molecular Formula
C30H50O
Molecular Weight
426.72
References & Citations
[1]Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43 (33) :10789-99.|[2]Aghaei M, et al Obtusifoliol related steroids��from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231) . Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP51; Trypanosoma
Available Sizes
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