Obtusifoliol

Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively[1].

Product Specifications

CAS Number

[16910-32-0]

UNSPSC

12352211

Target

Cytochrome P450; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/obtusifoliol.html

Purity

99.86

Solubility

DMSO : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

C=C(C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2(C)C(CC[C@@]3([H])[C@H](C)[C@@H](O)CC[C@]43C)=C4CC[C@]12C

Molecular Formula

C30H50O

Molecular Weight

426.72

References & Citations

[1]Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43 (33) :10789-99.|[2]Aghaei M, et al Obtusifoliol related steroids��from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231) . Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.