Hesperadin
Product Specifications
UNSPSC Description
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral[1][2][3].
Target Antigen
Aurora Kinase; Autophagy; Influenza Virus; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Autophagy;Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Hesperadin.html
Purity
98.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O
Molecular Weight
516.65
References & Citations
[1]Neal J, et, al. The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol Microbiol. 2009 Apr; 72(2): 442-58.|[2]Wahafu A, et, al. Targeting Aurora kinase B attenuates chemoresistance in glioblastoma via a synergistic manner with temozolomide. Pathol Res Pract. 2019 Nov; 215(11): 152617.|[3]Hu Y, et, al. Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral. Int J Mol Sci. 2017 Sep 8;18(9):1929.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12054/Hesperadin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12054/Hesperadin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
422513-13-1
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