(S)-MDL-101146
Product Specifications
UNSPSC Description
(S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1].
Target Antigen
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-mdl-101146.html
Smiles
O=C(NC([C@H](C(C)C)NC(C1=CC=C(C(N2CCOCC2)=O)C=C1)=O)=O)[C@H]3N([C@@H](C(C)C)C(C(F)(F)C(F)(F)F)=O)CCC3
Molecular Weight
632.62
References & Citations
[1]Angelastro MR, et al. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. J Med Chem. 1994 Dec 23;37(26):4538-53.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120039A/S-MDL-101146-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120039A/
Clinical Information
No Development Reported
CAS Number
163660-59-1
Curated Selection
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