Epetraborole
Product Specifications
UNSPSC Description
Epetraborole (GSK2251052) is a leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].
Target Antigen
Aminoacyl-tRNA Synthetase; Bacterial
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/epetraborole.html
Solubility
10 mM in DMSO
Smiles
OCCCOC1=C2C([C@H](OB2O)CN)=CC=C1
Molecular Weight
237.06
References & Citations
[1]Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4.|[2]O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.|[3]Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12479/Epetraborole-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12479/
Clinical Information
Phase 2
CAS Number
1093643-37-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP3-20131-0.2mg 0.2 mg
Rabbit Monoclonal PRMT5 Antibody (RAB-C136) - Chimeric - Azide and BSA Free
Ask
View Details 
