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Lesopitron

Lesopitron (E-4424) is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron inhibits forskolin-stimulated adenylate cyclase activity with an IC50 value of 125 nM[1].

Product Specifications

CAS Number

132449-46-8

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lesopitron.html

Solubility

10 mM in DMSO

Smiles

ClC1=CN(N=C1)CCCCN2CCN(CC2)C3=NC=CC=N3

Molecular Formula

C15H21ClN6

Molecular Weight

320.82

References & Citations

[1]S Haj-Dahmane, et al. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. Eur J Pharmacol. 1994.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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