Revdofilimab

Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells[1].

Product Specifications

CAS Number

[2230138-89-1]

Product Name Alternative

ABBV-368

UNSPSC

12352203

Target

Orexin Receptor (OX Receptor)

Type

Inhibitory Antibodies

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/revdofilimab.html

Purity

99.35

Solubility

10 mM in DMSO

Smiles

[Revdofilimab]

Molecular Weight

(145.62 kDa)

References & Citations

[1]A. Spira, et al. Safety, tolerability, and pharmacokinetics of the OX40 agonist ABBV-368 in patients with advanced solid tumors. ABSTRACTS IMMUNOTHERAPY OF CANCER| VOLUME 29, SUPPLEMENT 8, VIII409, OCTOBER 2018