2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

Product Specifications

CAS Number

[729589-58-6]

UNSPSC

12352209

Hazard Statement

H315, H319, H335

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-furoyl-ligrlo-amide.html

Purity

99.87

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC(C1=CC=CO1)=O)=O)=O)=O)=O)=O

Molecular Formula

C36H63N11O8

Molecular Weight

777.95

Precautions

H315, H319, H335

References & Citations

[1]McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309 (3) :1124-31.|[2]Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26 (7) :2877-87.|[3]Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol