What is the catalog number for Benzamil?

The catalog number for Benzamil is HY-B1546.

What sizes are available for Benzamil?

Benzamil is available in the following size(s): 1 Each.

Is Benzamil in stock?

Benzamil is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Benzamil?

Benzamil is manufactured by QuantiMol.

What is the estimated delivery time for Benzamil?

Estimated delivery time for Benzamil is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Benzamil?

The safety data sheet for Benzamil is available here: http://file.medchemexpress.com/batch_PDF/HY-B1546/.

Benzamil

Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM) . Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].

Product Specifications

CAS Number

2898-76-2

Product Name Alternative

Benzylamiloride

UNSPSC

12352005

Target

Na+/Ca2+ Exchanger; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/benzamil.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=CC=C2)=N

Molecular Formula

C13H14ClN7O

Molecular Weight

319.75

References & Citations

[1]Fischer KG, et al. Characterization of a Na (+) -Ca (2+) exchanger in podocytes. Nephrol Dial Transplant. 2002 Oct;17 (10) :1742-50.|[2]Wang X, et al. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008 Jul;295 (1) :F272-82.|[3]Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[4]Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738.|[5]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.