Benzamil
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM) . Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].
Product Specifications
CAS Number
2898-76-2
Product Name Alternative
Benzylamiloride
UNSPSC
12352005
Target
Na+/Ca2+ Exchanger; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/benzamil.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=CC=C2)=N
Molecular Formula
C13H14ClN7O
Molecular Weight
319.75
References & Citations
[1]Fischer KG, et al. Characterization of a Na (+) -Ca (2+) exchanger in podocytes. Nephrol Dial Transplant. 2002 Oct;17 (10) :1742-50.|[2]Wang X, et al. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008 Jul;295 (1) :F272-82.|[3]Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[4]Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738.|[5]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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