Alirocumab
Product Specifications
UNSPSC Description
Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia[1][2][3][4][5].
Target Antigen
PCSK9
Type
Inhibitory Antibodies
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/alirocumab.html
Purity
97.00
Solubility
H2O
Smiles
OC(CO)COP(O)(O)=O.[Na].[Na]
References & Citations
[1]Markham A. Alirocumab: First Global Approval. Drugs. 2015;75(14):1699-1705. |[2]Tavori H, et al. Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction. Expert Rev Cardiovasc Ther. 2014 Oct;12(10):1137-44.|[3]Ni X, et al. Establishment of an in vitro safety assessment model for lipid-lowering drugs using same-origin human pluripotent stem cell-derived cardiomyocytes and endothelial cells. Acta Pharmacol Sin. 2022 Jan;43(1):240-250.|[4]Kühnast S, et al. Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. J Lipid Res. 2014 Oct;55(10):2103-12.|[5]Huang HC, et al. Effects of PCSK-9 Inhibition by Alirocumab Treatments on Biliary Cirrhotic Rats. Int J Mol Sci. 2022 Jul 2;23(13):7378.
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4°C for 2 years, do not freeze
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P9928/Alirocumab-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P9928/Alirocumab-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1245916-14-6
Available Sizes
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