Sciadopitysin
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].
Product Specifications
CAS Number
[521-34-6]
UNSPSC
12352005
Target
NF-κB; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sciadopitysin.html
Purity
99.0
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(OC)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13
Molecular Formula
C33H24O10
Molecular Weight
580.54
References & Citations
[1]Briançon-Scheid F, et al. HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. Planta Med. 1983 Dec;49 (12) :204-7.|[2]Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents boneloss in LPS-treated mice. Int Immunopharmacol. 2017 Aug;49:109-117.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
Curated Selection
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