Siomycin A
Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1 (FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis[1][2].
Product Specifications
CAS Number
12656-09-6
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/siomycin-a.html
Solubility
10 mM in DMSO
Smiles
O=C1N[C@]23[C@@](N=C(C4=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS4)CC3)([H])C5=CSC([C@@]([C@H](OC(C6=CC([C@@H](O)C)=C7C([C@](O)([H])[C@@H](C=C7)N[C@](C(C)C)([H])C(NC(C(NC(C(N[C@H]1C)=O)=C)=O)=C)=O)=N6)=O)C)([H])NC(C8=CSC([C@](NC([C@]9([H])N=C(SC9)/C(NC(C([C@H](O)C)NC(C%10=CSC2=N%10)=O)=O)=C/C)=O)([H])[C@](C)(O)[C@H](O)C)=N8)=O)=N5
Molecular Formula
C71H81N19O18S5
Molecular Weight
1648.84
References & Citations
[1]Wang B, et al. Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells. Oncol Lett. 2019 Sep;18 (3) :2869-2876.|[2]Kim H, et al. Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. Neuropathol Appl Neurobiol. 2019 Jun 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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