γ-Oryzanol

γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM) .

Product Specifications

CAS Number

[11042-64-1]

UNSPSC

12352005

Hazard Statement

H310

Target

DNA Methyltransferase

Type

Natural Products

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/_gamma_-Oryzanol.html

Purity

99.66

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

[g-Oryzanol]

Molecular Weight

593.85 (average)

Precautions

H310

References & Citations

[1]Kozuka C, et al. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60 (8) :1502-1511.