γ-Oryzanol
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM) .
Product Specifications
CAS Number
[11042-64-1]
UNSPSC
12352005
Hazard Statement
H310
Target
DNA Methyltransferase
Type
Natural Products
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/_gamma_-Oryzanol.html
Purity
99.66
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
[g-Oryzanol]
Molecular Weight
593.85 (average)
Precautions
H310
References & Citations
[1]Kozuka C, et al. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60 (8) :1502-1511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
DNMT1; DNMT3
Available Sizes
Curated Selection
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