Molsidomine

Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200) . Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications[1][2].

Product Specifications

CAS Number

[25717-80-0]

Product Name Alternative

SIN-10; Morsydomine

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Molsidomine.html

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

O=C([N-]C1=C[N+](N2CCOCC2)=NO1)OCC

Molecular Formula

C9H14N4O4

Molecular Weight

242.23

Precautions

H302

References & Citations

[1]Vartzoka F, et al. The Nitric Oxide (NO) Donor Molsidomine Attenuates Memory Impairments Induced by the D1/D2 Dopaminergic Receptor Agonist Apomorphine in the Rat. Molecules. 2023 Sep 28;28 (19) :6861. |[2]Nayak B P, Minaz N, Pasha K. Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats. Animal Model Exp Med. 2021 Mar 23;4 (3) :243-248.