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SOD1 (UbetaB) Antibody (APC)

Rabbit polyclonal to SOD1 (APC) . Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4) . In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS) . Therefore conformation specific antibodies such as Anti-SOD1 (U beta B), which targets an unfolded region of the beta barrel of SOD1, are useful for determining the conformation of SOD1 in affected tissues. This antibody can be used in conjunction with Anti-SOD1 (EDI) (SPC-206D) which detects an exposed dimer interface (EDI) of SOD1.

Product Specifications

Product Name Alternative

SOD1 (UbetaB), SOD1, Superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SODC_HUMAN, ALS1, USOD, SOD1 unfolded beta barrel region, Misfolded SOD1, Conformationally altered SOD1, Apo-SOD1, Superoxide dismutase 1, SOD

UniProt

P00441

Reactivity

Human, Mouse, Rat

Immunogen

Within 50 AA of N-terminal region of SOD1, unfolded beta barrel region

Target

SOD1 (UbetaB)

Clonality

Polyclonal

Conjugation

APC

Field of Research

Metabolism Research

Purification

Peptide Affinity purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100)

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1μg/ml was sufficient for detection of the unfolded beta barrel of SOD1 by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Tested Applications

ELISA, ICC, IF, WB

NCBI Accession Number

CAG46542

Host or Source

Rabbit

Preservative

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Entrez

6647

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