Dehydrozingerone

Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM[1][2][3].

[1]He K, et al. Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens. J Asian Nat Prod Res. 2016 Jun;18(6):528-34.|[2]Kubra IR, et al. Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds. J Food Sci Technol. 2014 Feb;51(2):245-55.|[3]Song X, et al. Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors. J Agric Food Chem. 2019 Oct 16;67(41):11354-11363.