Bay Y5959

Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic[1][2].

Product Specifications

CAS Number

[146136-94-9]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bay-y5959.html

Smiles

CC(C)OC(C1=C(N)NC(C)=C(C#N)[C@H]1C2=CC=CC3=C2C=C(C4=CC=CC=C4)C=N3)=O

Molecular Formula

C26H24N4O2

Molecular Weight

424.49

References & Citations

[1]Pu J, et al. Effects of Bay Y5959 on Ca2+ currents and intracellular Ca2+ in cells that have survived in the epicardial border of the infarcted canine heart. J Cardiovasc Pharmacol. 1999 Jun;33 (6) :929-37. |[2]Bechem M, et al. A new type of Ca-channel modulation by a novel class of 1,4-dihydropyridines. Life Sci. 1997;60 (2) :107-18.