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Neuroligin 1 Antibody (HRP)

Mouse monoclonal to Neuroligin 1 (HRP) . Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord..

Product Specifications

Product Name Alternative

NLG 1, KIAA1070, MGC45115, Neuroligin-1, NL1, NLG1, Nlgn1

UniProt

Q62765

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical) . Human: 99% identity (125/126 amino acids identical) > 40% identity with Neuroligin-2 and -3.

Target

Neuroligin 1

Clonality

Monoclonal

Clone

N97A/31 (Formerly sold as S97A-31)

Conjugation

HRP

Field of Research

Disease Biomarkers, Neuroscience

Purification

Protein G Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100)

Molecular Weight

120kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

2 μg/ml was sufficient for detection of Neuroligin-1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Tested Applications

ICC, IF, IHC, WB

NCBI Accession Number

NP_446320.1

Host or Source

Mouse

Preservative

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate

Isotype

IgG1

Entrez

116647

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