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Mitofusin 2 Antibody (FITC)

Mouse monoclonal to Mitofusin 2 (FITC) . Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression..

Product Specifications

Product Name Alternative

Mitofusin 2, MFN2, Mfn2, Mitofusin-2, Transmembrane GTPase MFN2, Mitochondrial assembly regulatory factor, MARF, CMT2A, CMT2A2, CPRP1, CPRP 1, Fzo, HSG, Hyperplasia suppressor gene, Hypertension related protein 1, KIAA0214

UniProt

Q80U63

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical) . Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.

Target

Mitofusin 2

Clonality

Monoclonal

Clone

N153/5 (Formerly sold as S153-5)

Conjugation

FITC

Field of Research

Cancer Biology, Cell Biology, Disease Biomarkers, Neuroscience, Signal Transduction

Purification

Protein G Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100)

Molecular Weight

90kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1 μg/ml was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Tested Applications

ICC, IF, IHC, WB

NCBI Accession Number

NP_573464.2

Host or Source

Mouse

Preservative

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Isotype

IgG2a

Entrez

170731

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