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Ataxin 1 Antibody (PerCP)

Mouse monoclonal to Ataxin 1 (PerCP) . Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons..

Product Specifications

Product Name Alternative

Ataxin 1, Ataxin-1, ATX1, Atxn1, D6S504E, OTTHUMP00000016065, SCA1, Spinocerebellar ataxia type 1 protein

UniProt

P54254

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide amino acids 164-197 (ATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPP) of mouse Ataxin-1. Rat: 100% identity (34/34 amino acids identical) . Human: 88% identity (30/34 amino acids identical) .

Target

Ataxin 1

Clonality

Monoclonal

Clone

N76/8 (Formerly sold as S76-8)

Conjugation

PerCP

Field of Research

Epigenetics & Chromatin, Neuroscience, Signal Transduction

Purification

Protein G Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100)

Molecular Weight

85kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1 μg/ml was sufficient for detection of Ataxin-1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Tested Applications

ICC, IF, IHC, IP, WB

NCBI Accession Number

NP_001186233.1

Host or Source

Mouse

Preservative

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Isotype

IgG2b

Entrez

20238

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