LHRH (1-5) (free acid)

LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983) [1][2].

Product Specifications

CAS Number

[52434-75-0]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lhrh-1-5-free-acid.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1NC(CC1)=O)N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)CC3=CC=C(C=C3)O)=O)=O)CC4=CNC5=CC=CC=C45)=O

Molecular Formula

C34H38N8O9

Molecular Weight

702.71

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]McDermott JR, et al. Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. Peptides. 1983 Jan-Feb;4 (1) :25-30.|[2]Yokosawa H, et al. Degradation of luteinizing hormone-releasing hormone by neuroblastoma cells and their membrane: evidence for the involvement of a thiol protease and angiotensin-converting enzyme. J Neurochem. 1987 Jan;48 (1) :293-8.