NALCN Antibody (APC)
Mouse monoclonal to NALCN (APC) . NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events..
Product Specifications
Product Name Alternative
UniProt
Q6Q760
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Target
NALCN
Clonality
Monoclonal
Clone
N187/7 (Formerly sold as S187-7)
Conjugation
APC
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100)
Molecular Weight
200kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_705894.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
266760
Frequently Asked Questions
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