GSK2578215A
GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.
Product Specifications
CAS Number
1285515-21-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; LRRK2; Mitophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GSK2578215A.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=NC=CC(C2=CC(C(NC3=CC=CN=C3)=O)=C(OCC4=CC=CC=C4)C=C2)=C1
Molecular Formula
C24H18FN3O2
Molecular Weight
399.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22 (17) :5625-9.|[2]Saez-Atienzar S, et al. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis. 2014 Aug 14;5 (8) :e1368.|[3]Chen L, et al. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clin Transl Med. 2021 Mar;11 (3) :e341.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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