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ClCN3 Antibody (HRP)

Mouse monoclonal to Clcn3 (HRP) . Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory..

Product Specifications

Product Name Alternative

CIC3, CLC3, CLCN 3, Chloride channel 3, Chloride channel protein 3, Chloride channel, voltage-sensitive 3, Chloride transporter ClC 3, DKFZp564I0463, H (+) /Cl (-) exchange transporter 3, Chloride transporter ClC-3, ClC-3

UniProt

P51792

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3

Target

ClCN3

Clonality

Monoclonal

Clone

N258/5 (Formerly sold as S258-5)

Conjugation

HRP

Field of Research

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Purification

Protein G Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100)

Molecular Weight

90kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1 μg/ml was sufficient for detection of Clcn3 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Tested Applications

ICC, IF, IHC, WB

NCBI Accession Number

NP_445815.2

Host or Source

Mouse

Preservative

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate

Isotype

IgG1

Entrez

84360

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