PNR-7-02

PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ) . PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].

Product Specifications

CAS Number

[1633660-76-0]

UNSPSC

12352005

Target

Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pnr-7-02.html

Purity

98.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(NC(/C1=C\C2=CN(CC3=CC4=C(C=CC=C4)C=C3)C5=C2C=C(Cl)C=C5)=O)=S

Molecular Formula

C24H16ClN3O2S

Molecular Weight

445.92

References & Citations

[1]Zafar M K, et al. Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta[J]. The FASEB Journal, 2016, 30: 1052.3-1052.3.|[2]Ler AAL, et al. DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target. Front Oncol. 2022 Feb 7;11:822500.