GRL093-22
GRL093-22 is a potent and selective G protein-coupled receptor kinase (GRK) inhibitor, with IC50s of 60 and 40 nM for GRK5 and GRK6, respectively. GRL093-22 has the potential for the research of heart failure and multiple myeloma[1].
Product Specifications
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/grl093-22.html
Purity
99.51
Smiles
FC1=CC=C([C@H](NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C5=C(C)N=C6N5C=CC=C6)=O)=C(C)N4)=O)C3=C2)=O)C)C=C1
Molecular Formula
C33H29FN6O3
Molecular Weight
576.62
References & Citations
[1]Ghosh AK, et, el. Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors. Eur J Med Chem. 2025 Jan 15:282:117024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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