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Nav1.8 Antibody (Biotin)

Mouse monoclonal to Nav1 (Biotin) . 8. Nav1. 8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1. 8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1. 8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals..

Product Specifications

Product Name Alternative

Nav1.8, SCN10A, Scn10a, PN3, mPN3, Sns, SNS, Peripheral nerve sodium channel 3, Pn3 (gene name), Sensory neuron sodium channel, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8

UniProt

Q62968

Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Fusion protein amino acids 1724-1956 of rat Nav1.8

Target

Nav1.8

Clonality

Recombinant

Clone

S134

Conjugation

Biotin

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purification

Protein G Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100)

Molecular Weight

220kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1 μg/ml was sufficient for detection of Nav1.8 in 10 μg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Tested Applications

AM, ICC, IF, IHC, WB

NCBI Accession Number

NP_058943.1

Host or Source

Mouse

Preservative

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate

Isotype

IgG2a

Entrez

29571

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