ISIS 104838

Product Specifications

UNSPSC Description

ISIS 104838 is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.

Target Antigen

TNF Receptor

Type

Oligonucleotides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isis-104838.html

Solubility

10 mM in H2O

Smiles

[ISIS 104838]

Molecular Weight

7283.90

References & Citations

[1]Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303(3):1334-1343.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-145726/ISIS-104838-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-145726/ISIS-104838-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

250755-32-9

Available Sizes

Curated Selection

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