ISIS 104838

ISIS 104838 is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.

Product Specifications

CAS Number

[250755-32-9]

UNSPSC

12352208

Target

TNF Receptor

Type

Oligonucleotides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isis-104838.html

Purity

93.70

Solubility

10 mM in H2O

Smiles

[ISIS104838]

Molecular Weight

7283.90

References & Citations

[1]Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303 (3) :1334-1343.