ISIS 104838
Product Specifications
UNSPSC Description
ISIS 104838 is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.
Target Antigen
TNF Receptor
Type
Oligonucleotides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isis-104838.html
Solubility
10 mM in H2O
Smiles
[ISIS 104838]
Molecular Weight
7283.90
References & Citations
[1]Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303(3):1334-1343.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145726/ISIS-104838-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145726/ISIS-104838-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
250755-32-9
Available Sizes
Curated Selection
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