ISIS 104838
ISIS 104838 is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.
Product Specifications
CAS Number
[250755-32-9]
UNSPSC
12352208
Target
TNF Receptor
Type
Oligonucleotides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isis-104838.html
Purity
93.70
Solubility
10 mM in H2O
Smiles
[ISIS104838]
Molecular Weight
7283.90
References & Citations
[1]Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303 (3) :1334-1343.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Available Sizes
Curated Selection
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