MDC1 Antibody (RPE)
Mouse monoclonal to MDC1 (RPE) . MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A. X on S139..
Product Specifications
Product Name Alternative
MDC1, Nuclear factor with BRCT domains1, Mediator of DNA damage checkpoint 1
UniProt
Q5PSV9
Reactivity
Bovine, Human, Mouse, Primate
Immunogen
GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
Target
MDC1
Clonality
Monoclonal
Clone
P2B11
Conjugation
RPE
Field of Research
Metabolism Research; Epigenetics & Chromatin
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:2000), ICC/IF (1:100)
Molecular Weight
184kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
0.5 μg/ml was sufficient for detection of MDC1 in 10 μg of HeLa cell lysate by ECL immunoblot analysis.
Tested Applications
ICC, IF, WB
NCBI Accession Number
NP_001010833.2
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
240087
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