Reverse T3

Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].

Product Specifications

CAS Number

[5817-39-0]

Product Name Alternative

3′,5′,3-Triiodothyronine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/reverse-t3.html

Concentration

10mM

Purity

97.97

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

IC(C=C(C=C1)C[C@H](N)C(O)=O)=C1OC2=CC(I)=C(C(I)=C2)O

Molecular Formula

C15H12I3NO4

Molecular Weight

650.97

Precautions

H302, H315, H319, H335

References & Citations

[1]Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42 (5) :823-9. |[2]Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10 (10) :e0138749. |[3]Verga Falzacappa C, et al. 3,5,3'-triiodothyronine (T3) is a survival factor for pancreatic beta-cells undergoing apoptosis. J Cell Physiol. 2006 Feb;206 (2) :309-21.|[4]Bronson Kumar Khangembam, et al. Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth of atla catla larvae during ontogenic development, Aquaculture Research.13054, 48, 5, (2173-2185), (2016) .