Sulfopin
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1].
Product Specifications
CAS Number
[2451481-08-4]
Product Name Alternative
PIN1-3
UNSPSC
12352005
Hazard Statement
H315, H318, H335
Target
PIN1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfopin.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 4.35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl
Molecular Formula
C11H20ClNO3S
Molecular Weight
281.81
Precautions
H315, H318, H335
References & Citations
[1]Dubiella C, et al. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 2021;17 (9) :954-963.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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