Irosustat
Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity.
Product Specifications
CAS Number
288628-05-7
Product Name Alternative
STX64; BN83495; 667-Coumate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Steroid Sulfatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Irosustat.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1OC2=CC(OS(=O)(N)=O)=CC=C2C3=C1CCCCC3
Molecular Formula
C14H15NO5S
Molecular Weight
309.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Purohit A, et al. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 2000 Jul 1;60 (13) :3394-6.|[2]Raobaikady B, et al. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J Steroid Biochem Mol Biol. 2003 Feb;84 (2-3) :351-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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