GNE 220 (hydrochloride)
GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM.
Product Specifications
CAS Number
[2448286-21-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE_220_Hydrochloride.html
Purity
98.32
Solubility
DMSO : 5.4 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1.Cl
Molecular Formula
C25H27ClN8
Molecular Weight
474.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519 (7544) :425-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK; MAP4K5/KHS1; MAP4K6/MINK1
Available Sizes
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