Juglone

Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity [1][2][3].

Product Specifications

CAS Number

[481-39-0]

Product Name Alternative

5-Hydroxy-1,4-naphthalenedione

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Bacterial; NF-κB; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/juglone.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : ≥ 3.33 mg/mL

Smiles

O=C(C1=C2C=CC=C1O)C=CC2=O

Molecular Formula

C10H6O3

Molecular Weight

174.16

Precautions

H301

References & Citations

[1]Zmantar T, et al. Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. Microb Pathog. 2016 Dec;101:44-49.|[2]Ji YB, et al. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 2011 Jan;63 (1-2) :69-78.|[3]Peng X, et al. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun. 2015 Jul 3;462 (3) :245-50.