USP25/28 inhibitor AZ1
USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model[1][2].
Product Specifications
CAS Number
[2165322-94-9]
Product Name Alternative
AZ1
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/usp25-28-inhibitor-az1.html
Purity
98.0
Solubility
DMSO : ≥ 250 mg/mL
Smiles
FC(C1=CC(COC2=CC=C(Br)C=C2CNCCO)=CC=C1F)(F)F
Molecular Formula
C17H16BrF4NO2
Molecular Weight
422.21
Precautions
H315, H319, H320
References & Citations
[1]Wrigley JD, et al. Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating EnzymeSubfamily. ACS Chem Biol. 2017 Dec 15;12 (12) :3113-3125.|[2]Xiao-Meng Wang, et al. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nature Cancer volume 1, pages811–825 (2020) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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