KSI-6666
KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].
Product Specifications
CAS Number
[1807873-14-8]
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ksi-6666.html
Purity
96.15
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
CCN(C(C1=CC=C(C(CN2CC(C2)C(O)=O)=C1)C)C)C3=CC=C(C(C(F)(F)F)=C3)Cl
Molecular Formula
C23H26ClF3N2O2
Molecular Weight
454.91
References & Citations
[1]Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR1
Available Sizes
Curated Selection
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