KSI-6666

KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].

Product Specifications

CAS Number

[1807873-14-8]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ksi-6666.html

Purity

96.15

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

CCN(C(C1=CC=C(C(CN2CC(C2)C(O)=O)=C1)C)C)C3=CC=C(C(C(F)(F)F)=C3)Cl

Molecular Formula

C23H26ClF3N2O2

Molecular Weight

454.91

References & Citations

[1]Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826.