Human GDNF / ATF / hGDNF Protein (E. coli), premium grade
Human GDNF Protein (E. coli), premium grade (GDF-H5118) is expressed from E. coli cells. It contains AA Ser 78 - Ile 211 (Accession # P39905-1) .
Product Specifications
Background
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.
Specifications
This protein carries no "tag". The protein has a calculated MW of 15.2 kDa. The protein migrates as 15 kDa±3 kDa under reducing (R) condition, and 30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE)
Accession Number
P39905-1
Expression Region
Ser 78 - Ile 211
Host
E. coli
Target
GDNF
Conjugation
Unconjugated
Tag
Native
Stability
● -20°C to -70°C for 24 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.01 EU per μg
Purity
95%
Format
Powder
Buffer
20 mM Sodium Citrate, 150 mM NaCl, pH4.0
Additives
Trehalose
Molecular Weight
15.2 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
20ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/GDF-H5118.pdf
Species
Human
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