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Xenin-8

Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM) [1].

Product Specifications

CAS Number

[117442-28-1]

UNSPSC

12352209

Target

Insulin Receptor; Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/xenin-8.html

Solubility

H2O

Smiles

O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H]2N(CCC2)C([C@@H](N)CC3=CNC=N3)=O)=O)=O)=O)N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC4=CNC5=C4C=CC=C5

Molecular Formula

C51H79N15O9

Molecular Weight

1046.27

References & Citations

[1]Ramona A Silvestre, et al. Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul Pept. 2003 Aug 15;115 (1) :25-9.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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