(Rac) -Razpipadon

PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP) [1].

Product Specifications

CAS Number

[1643462-93-4]

Product Name Alternative

PW0464

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pw0464.html

Purity

97.09

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3OC(F)F)C=C2C)N1C)=O

Molecular Formula

C19H17F2N3O4

Molecular Weight

389.35

References & Citations

[1]Pingyuan Wang, et al. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med Chem Lett|[2]David R Sibley, et al. Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential. Signal Transduct Target Ther. 2021 May 22;6 (1) :205.