Estrone O-sulfamate

Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer[1].

Product Specifications

CAS Number

[148672-09-7]

Product Name Alternative

Estrone 3-O-sulfamate

UNSPSC

12352005

Target

Steroid Sulfatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/estrone-o-sulfamate.html

Purity

99.99

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OS(N)(=O)=O)C=C4CC3

Molecular Formula

C18H23NO4S

Molecular Weight

349.44

References & Citations

[1]L W Lawrence Woo, et al. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorg Med Chem. 2012 Apr 15;20 (8) :2506-19.